Research-use information only. This page summarises published laboratory findings on 5-amino-1MQ. Material supplied by Peptides Lab UK is for laboratory research use only, not for human or veterinary use, and nothing here is medical or dosing advice.
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme increasingly studied in adipose-tissue metabolism. By inhibiting NNMT, the compound is reported to raise intracellular NAD+ and preserve the cellular methylation pool — the mechanism behind its interest in metabolic and body-composition research. Like SLU-PP-332, it is a small molecule rather than a peptide.
What 5-amino-1MQ is
5-Amino-1MQ is a synthetic quinolinium compound. NNMT, its target, is an enzyme that methylates nicotinamide using S-adenosylmethionine (SAM) as the methyl donor. NNMT is highly expressed in adipose tissue and the liver, and elevated NNMT activity has been associated in the literature with obesity and metabolic dysfunction — which is what made its inhibition a research target.
How 5-amino-1MQ is described to work
NNMT sits at the intersection of two important cellular currencies: the NAD+ salvage pathway and the SAM methylation pool. Inhibiting it is reported to have two linked effects:
- NAD+ preservation — nicotinamide that would otherwise be methylated and excreted is instead retained for NAD+ regeneration, supporting the sirtuin and PARP pathways that depend on it.
- Methylation-pool preservation — less SAM is consumed in nicotinamide methylation, altering the availability of methyl groups for other reactions.
In preclinical adipocyte and animal models, NNMT inhibition is reported to increase cellular energy expenditure and reduce fat storage.
Research context and evidence honesty
The 5-amino-1MQ evidence base is preclinical — cell and rodent models — with limited controlled human data. Its mechanism is well defined and the NNMT target is biologically credible, but conclusions about human weight or metabolic outcomes are not supported by the current literature. This should be treated as an open research question rather than an established effect.
Where it sits among metabolic research compounds
5-Amino-1MQ acts on enzyme-level NAD+ and methylation biology — a different axis again from the ERR transcriptional mechanism of SLU-PP-332 or the growth-hormone-fragment mechanism of AOD-9604. Researchers studying metabolic pathways sometimes examine these in parallel precisely because they intervene at separate points.
Dosage and handling as described in the literature
As a small molecule, 5-amino-1MQ is handled by small-molecule conventions rather than peptide reconstitution norms; the appropriate solvent depends on the supplied form. Published protocols describe milligram-per-kilogram dosing in animal models. These describe research documentation only and are not instructions for human use. Confirm the correct diluent for the specific preparation rather than assuming bacteriostatic water.
The UK regulatory position
5-Amino-1MQ is not a licensed medicine in the UK and is not approved for human consumption. Peptides Lab UK supplies it for laboratory research only, correctly labelled. Insist on batch-specific analytical data; our quality-standards SOP sets out the testing applied to every batch.
Frequently asked questions
What is 5-amino-1MQ?
A small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), studied in adipose-tissue metabolism for its reported effects on NAD+ levels and cellular methylation.
Is 5-amino-1MQ a peptide?
No. It is a small molecule despite appearing in research-peptide catalogues, and is handled by small-molecule conventions.
How does 5-amino-1MQ work?
By inhibiting NNMT, it is reported to preserve nicotinamide for NAD+ regeneration and reduce consumption of the SAM methylation pool, effects associated in preclinical models with increased energy expenditure.
Is there human data on 5-amino-1MQ?
Limited. The evidence base is largely preclinical, and human metabolic outcomes are not established.
How is 5-amino-1MQ stored and prepared?
By small-molecule conventions; the correct solvent depends on the supplied form. Confirm the appropriate diluent rather than assuming bacteriostatic water.
Is 5-amino-1MQ legal in the UK?
It is not a licensed medicine in the UK. Supply for laboratory research, correctly labelled, is a separate lawful category.
Disclaimer: this content is for educational and research purposes only. 5-Amino-1MQ supplied by Peptides Lab UK is not intended for human or veterinary use.
